Loline Alkaloid Effects on Gastrointestinal Nematodes

Loline Alkaloid Effects on Gastrointestinal Nematodes

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Loline, an alkaloid with several derivatives, has suggested antimicrobial and anthelmintic properties.Therefore, loline was investigated as a natural mpu63zm/a anthelmintic against Trichostrongylus colubriformis, Teladorsagia circumcincta, and Haemonchus contortus.Preliminary in vitro studies had reduced L3 T.circumcincta establishment but no effect on L3 T.

colubriformis larvae migration or H.contortus establishment.While loline-treated lambs had lower establishment of L4 and adult T.circumcincta and L4 T.

colubriformis, L4 and adult H.contortus appeared unaffected.Following preliminary study, an in vivo experiment examined lambs infected with a mix of L4 T.circumcincta, T.

colubriformis, and adult H.contortus.These lambs were treated with either a loline seed extract (LOL, n = 7), nothing (CON, n = 7), or a non-loline seed extract (NIL, n = 2).There were no differences in worm burdens, fecal egg counts, weight gain, or feed intake between treatments.

However, an average growth efficiency (kg skittles ornament LWG/kg DM intake) was detected (p = 0.01) in CON (0.18) which was less than LOL (0.24) or NIL (0.

23).There was limited evidence to support an in vivo anti-parasitic effect of loline despite in vitro studies indicating potential benefits.Discrepancies between in vivo and in vitro studies results were potentially a result of loline contact time with larvae, mode of ingestion or the forms of loline present.